A Bioactive Substance Derived from Brown Seaweeds: Phlorotannins

Hongli Zheng; Yanan Zhao; Lei Guo

PMC · DOI:10.3390/md20120742·November 26, 2022·90 cites

A Bioactive Substance Derived from Brown Seaweeds: Phlorotannins

Hongli Zheng, Yanan Zhao, Lei Guo

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Open Access

TL;DR

This paper reviews phlorotannins, natural compounds from brown algae with various health benefits, and their potential uses in medicine, food, and cosmetics.

Contribution

The paper provides a comprehensive review of phlorotannins' extraction, separation, and biological activities.

Findings

01

Phlorotannins exhibit antioxidant, antibacterial, antiviral, and anti-inflammatory activities.

02

They are primarily used in medicine, food, and cosmetics due to their diverse biological functions.

03

The paper highlights recent advances in the extraction and separation technologies of phlorotannins.

Abstract

Phlorotannins are a type of natural active substance extracted from brown algae, which belong to a type of important plant polyphenol. Phloroglucinol is the basic unit in its structure. Phlorotannins have a wide range of biological activities, such as antioxidant, antibacterial, antiviral, anti-tumor, anti-hypertensive, hypoglycemic, whitening, anti-allergic and anti-inflammatory, etc. Phlorotannins are mainly used in the fields of medicine, food and cosmetics. This paper reviews the research progress of extraction, separation technology and biological activity of phlorotannins, which will help the scientific community investigate the greater biological significance of phlorotannins.

Linked entities

Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.

Genes45

MSTN FCER1A Trp2 RAC1 TNF OGA ACHE Mmp13 Mmp1 IGHE TYRP1 SI BCHE Fdxr ACE Il1b AKR1B1 Akt1 PTGDS PTK2 EGFR APP INS COX2 TYR Sis FN1 MMP13 Egfr DCT CDH1 NFKB1 CRP Tyr App PPARG Bcl2 Mmp3 Tnf MMP2 Bax Bace1 IGF1 MMP9 MMP1

Proteins24

Species52

Phaeophyceae(brown algae · class)Cystoseira compressa(species)Lessonia nigrescens(species)Saccharina japonica(species)Bifurcaria bifurcata(species)Codium tomentosum(species)Homo sapiens(human · species)Polycladia myrica H1N1 subtype(serotype)Sargassum thunbergii(species)Undaria pinnatifida(species)Fucus evanescens(species)Fucus vesiculosus(species)Rattus norvegicus(brown rat · species)Carpophyllum flexuosum(species)Sargassum horneri(species)Sargassum muticum(Japanese wireweed · species)Eisenia bicyclis(species)Gallus gallus(bantam · species)Halocynthia roretzi(species)Chorda filum(species)Ecklonia cava(species)Ecklonia kurome Silvetia siliquosa(species)Costaria costata(seersucker kelp · species)Candida albicans(species)Aspergillus(genus)Fucus spiralis(species)PX clade(clade)Ciona savignyi(Pacific transparent sea squirt · species)Ascophyllum nodosum(species)Arthrodermataceae(dermatophytes · family)Ecklonia arborea(species)Carpophyllum plumosum(species)Sargassum miyabei(species)Ecklonia stolonifera Saccharina cichorioides(species)Macrocystis pyrifera(giant kelp · species)Ecklonia maxima(species)Sargassum swartzii(species)Sargassum fusiforme(species)Mus musculus(house mouse · species)Vibrio parahaemolyticus(species)Pseudomonas aeruginosa(species)Canis lupus familiaris(dog · subspecies)H9N2 subtype(serotype)Severe acute respiratory syndrome-related coronavirus(no rank)Laminaria ochroleuca(species)Ulva armoricana(species)Gammacoronavirus(genus)Caenorhabditis elegans(species)Sargassum carpophyllum(species)

Cell lines18

Chemicals1

Phloroglucinol

Diseases60

AD cerebrovascular disease necrosis COVID-19 -cancer neurotoxicity narcolepsy metabolic disorders asthma virus articular diseases Diabetic weight loss constipation liver damage Hypercholesterolemia plaques colorectal adenocarcinoma ovarian cancer macrophage leukemia diabetes mellitus type 2 atherosclerosis allergic rhinitis condition sarcoma inflammation gastric cancer Pain Carcinogenesis wrinkle rapid eye movement sleep liver central nervous system diseases heart failure kidney tumor necrosis factor hyperlipidemia overweight allergic osteosarcoma malaria food allergies cognitive dysfunction Cytotoxicity cardiovascular and cerebrovascular disease hypertension Alzheimer's neuroinflammation neuronal dysfunction, degeneration inflammatory cytokines inflammation of the gastrointestinal tract heart attack colorectal coronary heart disease Obesity SARS Induces inflammatory arthritis AS03 EAE AIDS hypoglycemic

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Taxonomy

TopicsSeaweed-derived Bioactive Compounds · Phytochemical and Pharmacological Studies · Algal biology and biofuel production