Transcriptome Profiling and Molecular Pathway Analysis of Genes in Association with Salinity Adaptation in Nile Tilapia Oreochromis niloticus
Zhixin Xu, Lei Gan, Tongyu Li, Chang Xu, Ke Chen, Xiaodan Wang, Jian G. Qin, Liqiao Chen, Erchao Li
TL;DR
This study explores how Nile tilapia adapt to different salinity levels by analyzing gene expression and molecular pathways.
Contribution
The study identifies three categories of gene expression changes and their associated pathways in response to salinity stress in Nile tilapia.
Findings
Steroid biosynthesis and related pathways are significantly affected by salinity stress.
Ribosomes and oxidative phosphorylation show sensitivity to salinity variation.
Protein export and thyroid hormone synthesis pathways are less sensitive to salinity changes.
Abstract
Nile tilapia Oreochromis niloticus is a freshwater fish but can tolerate a wide range of salinities. The mechanism of salinity adaptation at the molecular level was studied using RNA-Seq to explore the molecular pathways in fish exposed to 0, 8, or 16 (practical salinity unit, psu). Based on the change of gene expressions, the differential genes unions from freshwater to saline water were classified into three categories. In the constant change category (1), steroid biosynthesis, steroid hormone biosynthesis, fat digestion and absorption, complement and coagulation cascades were significantly affected by salinity indicating the pivotal roles of sterol-related pathways in response to salinity stress. In the change-then-stable category (2), ribosomes, oxidative phosphorylation, signaling pathways for peroxisome proliferator activated receptors, and fat digestion and absorption changed…
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Taxonomy
TopicsSystemic Sclerosis and Related Diseases · Diagnosis and Treatment of Venous Diseases · Abdominal vascular conditions and treatments