LC/MS/MS data analysis of the human uterine smooth muscle S-nitrosoproteome fingerprint in pregnancy, labor, and preterm labor
Craig C. Ulrich, David R. Quilici, Karen A. Schlauch, Heather R. Burkin, Iain L.O. Buxton
TL;DR
This study uses mass spectrometry to analyze protein modifications in uterine muscle during pregnancy, labor, and preterm labor.
Contribution
The novel contribution is identifying S-nitrosoproteome differences in human uterine smooth muscle under various labor conditions.
Findings
S-nitrosoproteome fingerprints differ between laboring and non-laboring uterine tissues.
Preterm labor tissues show distinct S-nitrosoproteome profiles after S-nitrosoglutathione treatment.
Mass spectrometry reveals large-scale changes in protein nitrosylation during labor states.
Abstract
The data described in this article is the subject of an article in the American Journal of Physiology: Cell Physiology, titled “The Human Uterine Smooth Muscle S-nitrosoproteome Fingerprint in Pregnancy, Labor, and Preterm Labor” (doi:10.1152/ajpcell.00198.2013) (Ulrich et al., 2013) [1]. The data described is a large scale mass spectrometry data set that defines the human uterine smooth muscle S-nitrosoproteome differences among laboring, non-laboring, preterm laboring tissue after treatment with S-nitrosoglutathione.
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Taxonomy
TopicsNitric Oxide and Endothelin Effects · Pregnancy and preeclampsia studies · Birth, Development, and Health