In Vitro Modeling of Mycelium Biomass Growth Kinetics of the Novel Fungicolous Species Xylaria karsticola NBIMCC 9097, with Insights into Its Antimicrobial Potential
Galena Angelova, Zlatka Ganeva, Bogdan Goranov, Nikoleta Kaneva, Mariya Brazkova, Petya Stefanova, Denica Blazheva
TL;DR
A rare fungus called Xylaria karsticola was studied for its growth and ability to fight microbes, showing promising antimicrobial properties.
Contribution
This study provides the first in vitro growth modeling and antimicrobial evaluation of the novel fungicolous species Xylaria karsticola.
Findings
Optimized media increased biomass yields to 20.11 and 23.25 g/dm³ in MCM and MYB media, respectively.
Hexane and ethyl acetate extracts showed strong antimicrobial activity against Pseudomonas aeruginosa and several yeast species.
Water biomass extract exhibited the lowest MIC of 0.02 mg/cm³ against Saccharomycodes ludwigii.
Abstract
Xylaria karsticola NBIMCC 9097 is a recently described and rare fungicolous species originating from Bulgaria. Understanding its growth behavior and bioactive potential is essential for evaluating its biotechnological and pharmaceutical relevance. In the presented study, we model the in vitro growth kinetics of X. karsticola mycelium under submerged cultivation and assess its antimicrobial activity. Optimization of MCM and MYB media markedly increased biomass yields to 20.11 and 23.25 g/dm3, respectively, compared with non-optimized media (9.9 ± 0.21 and 10.8 ± 0.28 g/dm3). The maximum specific growth rate was higher in the MCM (0.803 ± 0.004 h−1) in comparison with the MYB medium (0.711 ± 0.003 h−1); however, the MYB medium supported greater biomass accumulation and more efficient substrate utilization, reflected by a higher utilization coefficient (0.9900 ± 0.001 versus 0.9644 ±…
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Taxonomy
TopicsPlant and Biological Electrophysiology Studies · Microbial Natural Products and Biosynthesis · Slime Mold and Myxomycetes Research