T-cell receptor anti-CMV CDR3s from bone marrow samples are associated with a worse overall survival for recurrent acute myeloid leukemia
Srijit Paul, Michael T. Aboujaoude, Vayda R. Barker, Tabitha R. Hudock, Arpan Sahoo, George Blanck
TL;DR
T-cell receptors targeting CMV in bone marrow samples are linked to worse survival in children with recurring acute myeloid leukemia.
Contribution
This study identifies a novel association between anti-viral TCRs in bone marrow and poor survival in pediatric AML patients.
Findings
Anti-CMV TCR CDR3s in recurrent AML bone marrow samples correlate with decreased overall survival.
Anti-EBV TCR CDR3s in recurrent AML bone marrow samples also show reduced survival probabilities.
The study suggests a possible link between viral infections and AML outcomes.
Abstract
We assessed the relationship of AML patient outcomes and T-cell receptor (TCR) recombination reads representing known anti-viral TCR sequences. TCR complementary determining region-3′s (CDR3s) were obtained from the pediatric TARGET-AML dataset, and the TCR CDR3s representing bone marrow samples of primary and recurrent disease were matched to anti-viral TCR CDR3s. The patients representing the presence of the anti-viral CDR3s were then assessed for overall survival (OS). Patients with anti-CMV TCR CDR3s from bone marrow samples representing recurrent AML showed a significant decrease in OS probability. Decreases in OS probabilities were also observed for patients with anti-Epstein Barr Virus (EBV) TCR CDR3s obtained from recurrent AML, bone marrow samples. Overall, this study raises the question of whether there is a relationship between viral infections, or the basic impact of…
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Taxonomy
TopicsCAR-T cell therapy research · Hematopoietic Stem Cell Transplantation · T-cell and B-cell Immunology