Immediate implant placement with and without platelet-rich fibrin and decalcified freeze-dried bone graft

TL;DR

Using a combination of PRF and DFDBA graft improves bone and tissue preservation, stability, and aesthetics in immediate dental implant placement.

Contribution

Demonstrates that PRF and DFDBA grafting improves outcomes in immediate implant placement compared to no grafting.

Findings

PRF and DFDBA grafting significantly preserves vertical and horizontal bone levels.

Implant stability and esthetic scores improved with the use of the graft composite.

Statistical analysis confirmed significant differences between grafted and non-grafted groups.

Abstract

There is a high risk of vertical and horizontal bone resorption in the peri-implant gap following immediate implant placement after
non-molar tooth extraction, which compromises implant stability, hard/soft tissue preservation, and esthetic outcomes. The present
study was a randomized controlled clinical trial included 40 patients requiring a single non-molar tooth extraction and immediate
implant placement. Patients were randomly allocated into two equal groups (n=20). In the Test group, the peri-implant gap was filled
with a composite of PRF and DFDBA. In the Control group, no grafting material was placed. The primary outcome was vertical bone level
(VBL) change at 6 months, measured on standardized radiographs. Secondary outcomes included horizontal bone thickness changes measured
on CBCT, implant stability quotient (ISQ) at baseline and 3 months and Pink Esthetic Score (PES) at 6 months. Independent t-tests were
used for statistical analysis (α=0.05). The adjunctive use of a composite PRF and DFDBA graft in immediate implant placement
sockets significantly improves the preservation of peri-implant hard and soft tissues, enhances secondary implant stability and leads to
superior esthetic outcomes compared to no grafting.