# Immediate implant placement with and without platelet-rich fibrin and decalcified freeze-dried bone graft

## TL;DR

Using a combination of PRF and DFDBA graft improves bone and tissue preservation, stability, and aesthetics in immediate dental implant placement.

## Contribution

Demonstrates that PRF and DFDBA grafting improves outcomes in immediate implant placement compared to no grafting.

## Key findings

- PRF and DFDBA grafting significantly preserves vertical and horizontal bone levels.
- Implant stability and esthetic scores improved with the use of the graft composite.
- Statistical analysis confirmed significant differences between grafted and non-grafted groups.

## Abstract

There is a high risk of vertical and horizontal bone resorption in the peri-implant gap following immediate implant placement after
non-molar tooth extraction, which compromises implant stability, hard/soft tissue preservation, and esthetic outcomes. The present
study was a randomized controlled clinical trial included 40 patients requiring a single non-molar tooth extraction and immediate
implant placement. Patients were randomly allocated into two equal groups (n=20). In the Test group, the peri-implant gap was filled
with a composite of PRF and DFDBA. In the Control group, no grafting material was placed. The primary outcome was vertical bone level
(VBL) change at 6 months, measured on standardized radiographs. Secondary outcomes included horizontal bone thickness changes measured
on CBCT, implant stability quotient (ISQ) at baseline and 3 months and Pink Esthetic Score (PES) at 6 months. Independent t-tests were
used for statistical analysis (α=0.05). The adjunctive use of a composite PRF and DFDBA graft in immediate implant placement
sockets significantly improves the preservation of peri-implant hard and soft tissues, enhances secondary implant stability and leads to
superior esthetic outcomes compared to no grafting.