Assessment of chronic liver disease using shear wave elastography: Correlation with serum markers
Soumik Pal, Rajeev Kumar Ranjan, Suresh Kumar Toppo, Mohd Ismail, Harish Shivprasad Gupta, Sonali Priyadarsini Reddy, Md Shahrukh Ansari
TL;DR
This study shows that shear wave elastography is a reliable non-invasive tool for assessing liver fibrosis in chronic liver disease patients.
Contribution
The study identifies optimal SWE cutoffs and confirms strong correlations with serum markers like APRI.
Findings
SWE strongly correlates with APRI (r=0.70) and platelet count (r=-0.70).
Optimal SWE cutoffs for significant fibrosis and cirrhosis are 9.2 kPa and 15.38 kPa, respectively.
Combining SWE with APRI provides a reliable non-invasive fibrosis assessment.
Abstract
Chronic liver disease requires accurate fibrosis assessment, with non-invasive tools gaining importance over biopsy. Hence, this cross- sectional study evaluated liver fibrosis in 122 CLD patients using shear wave elastography (SWE) and correlated findings with serum markers. SWE showed strong correlation with APRI (r=0.70) and platelet count (r=-0.70), and moderate correlations with AST and FIB-4. Optimal SWE cutoffs were 9.2 kPa for significant fibrosis and 15.38 kPa for cirrhosis, with excellent diagnostic accuracy (AUROC=0.99). SWE combined with serum markers-especially APRI-provides a reliable, non-invasive alternative for fibrosis assessment in CLD patients.
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Taxonomy
TopicsLiver Disease Diagnosis and Treatment · Ultrasound Imaging and Elastography · Liver Disease and Transplantation