lsaC and Tandem lsaE-lnuB Resistance Genes in Invasive Group A Streptococcus
Bernard Beall, Saundra Mathis, Zhongya Li, Joy Rivers, Anne-Kathryn Venero, Benjamin J. Metcalf, Lesley McGee, Sopio Chochua
TL;DR
This study identifies new resistance genes in invasive Streptococcus pyogenes, which could impact treatment options for infections.
Contribution
The detection of 9 independent acquisitions of lsaC or tandem lsaE-lnuB resistance genes in S. pyogenes isolates is reported.
Findings
lsaC or tandem lsaE-lnuB genes were found in 9 invasive S. pyogenes isolates.
These genes confer resistance to pleuromutilins and clindamycin.
Monitoring resistance gene evolution in S. pyogenes is crucial for treatment strategies.
Abstract
Among >16,500 recently recovered invasive Streptococcus pyogenes isolates, we detected 9 independent acquisitions of lsaC or tandem lsaE-lnuB genes, which are known to confer resistance to pleuromutilins and clindamycin. Continued awareness of the evolving S. pyogenes antimicrobial resistosome is important for future infection treatment considerations.
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Taxonomy
TopicsStreptococcal Infections and Treatments · Neonatal and Maternal Infections · Oral microbiology and periodontitis research