# lsaC and Tandem lsaE-lnuB Resistance Genes in Invasive Group A Streptococcus

## TL;DR

This study identifies new resistance genes in invasive Streptococcus pyogenes, which could impact treatment options for infections.

## Contribution

The detection of 9 independent acquisitions of lsaC or tandem lsaE-lnuB resistance genes in S. pyogenes isolates is reported.

## Key findings

- lsaC or tandem lsaE-lnuB genes were found in 9 invasive S. pyogenes isolates.
- These genes confer resistance to pleuromutilins and clindamycin.
- Monitoring resistance gene evolution in S. pyogenes is crucial for treatment strategies.

## Abstract

Among >16,500 recently recovered invasive Streptococcus pyogenes isolates, we detected 9 independent acquisitions of lsaC or tandem lsaE-lnuB genes, which are known to confer resistance to pleuromutilins and clindamycin. Continued awareness of the evolving S. pyogenes antimicrobial resistosome is important for future infection treatment considerations.