Quercetin and Derivatives Ameliorate Metabolic Disturbances by Regulating Gut Metabolite Profiles in Mice with Circadian Rhythm Disruption and High-Fat Diet
Hao Jiang, Yiling Xie, Xiaoqing Zheng, Jiali Lai, Xiangyun Chen, Xiantao Zheng, Hongwei Zhao, Weidong Bai
TL;DR
Quercetin and its derivatives help reduce metabolic issues in mice caused by disrupted sleep and high-fat diets by changing gut metabolites.
Contribution
The study demonstrates quercetin's ability to regulate gut metabolites in a dual model of circadian and dietary stress.
Findings
Quercetin and derivatives significantly altered intestinal metabolite profiles in mice.
Metabolic abnormalities from circadian disruption and high-fat diets were alleviated.
Findings support quercetin's potential in functional food development for metabolic health.
Abstract
Background: Amidst evolving modern lifestyles characterized by widespread circadian rhythm disturbances and high-fat dietary habits, the incidence of metabolic disorders continues to escalate. In recent years, plant-derived bioactive compounds have attracted considerable interest as therapeutic candidates, with quercetin and its derivatives demonstrating promising potential for the regulation of metabolism. Methods: This study employed a dual-induction model of metabolic dysregulation, elicited through both circadian rhythm disruption and a high-fat diet, to systematically evaluate the regulatory effects of quercetin and its derivatives on mice through dual stimulation by circadian rhythm disruption and a high-fat diet. Results and Conclusions: Non-targeted fecal metabolomics analysis indicates that quercetin and its derivatives significantly alter the intestinal metabolite profile in…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsCircadian rhythm and melatonin · Metabolomics and Mass Spectrometry Studies · Diet and metabolism studies