# Quercetin and Derivatives Ameliorate Metabolic Disturbances by Regulating Gut Metabolite Profiles in Mice with Circadian Rhythm Disruption and High-Fat Diet

## TL;DR

Quercetin and its derivatives help reduce metabolic issues in mice caused by disrupted sleep and high-fat diets by changing gut metabolites.

## Contribution

The study demonstrates quercetin's ability to regulate gut metabolites in a dual model of circadian and dietary stress.

## Key findings

- Quercetin and derivatives significantly altered intestinal metabolite profiles in mice.
- Metabolic abnormalities from circadian disruption and high-fat diets were alleviated.
- Findings support quercetin's potential in functional food development for metabolic health.

## Abstract

Background: Amidst evolving modern lifestyles characterized by widespread circadian rhythm disturbances and high-fat dietary habits, the incidence of metabolic disorders continues to escalate. In recent years, plant-derived bioactive compounds have attracted considerable interest as therapeutic candidates, with quercetin and its derivatives demonstrating promising potential for the regulation of metabolism. Methods: This study employed a dual-induction model of metabolic dysregulation, elicited through both circadian rhythm disruption and a high-fat diet, to systematically evaluate the regulatory effects of quercetin and its derivatives on mice through dual stimulation by circadian rhythm disruption and a high-fat diet. Results and Conclusions: Non-targeted fecal metabolomics analysis indicates that quercetin and its derivatives significantly alter the intestinal metabolite profile in mice, alleviating metabolic abnormalities induced by circadian rhythm disruption and high-fat diet. These findings provide a theoretical basis for the future development of quercetin-based functional food products.