Interim Estimates of 2025–26 Seasonal Influenza Vaccine Effectiveness — United States, September 2025–February 2026

Patrick Maloney; Emily L. Reeves; Kristina Wielgosz; Ashley M. Price; Karthik Natarajan; Malini B. DeSilva; Kristin Dascomb; Nicola P. Klein; Sara Y. Tartof; Stephanie A. Irving; Shaun J. Grannis; Toan C. Ong; Zachary A. Weber; Jennifer E. Schuster; Danielle M. Zerr; Marian G. Michaels; Julie A. Boom; Natasha B. Halasa; Mary A. Staat; Geoffrey A. Weinberg; Stacey L. House; Elie A. Saade; Krissy Moehling Geffel; Manjusha Gaglani; Karen J. Wernli; Vel Murugan; Emily T. Martin; Natalie A. B. Bontrager; Marie K. Kirby; Amanda B. Payne; Fatimah S. Dawood; Ayzsa Tannis; Heidi L. Moline; Sifang Kathy Zhao; Katherine Adams; Jennifer DeCuir; Samantha M. Olson; Jessie R. Chung; Nathaniel Lewis; Brendan Flannery; Carrie Reed; Shikha Garg; Sascha Ellington; Omobosola Akinsete; Sarah W. Ball; Michelle A. Barron; Daniel Bride; Brian E. Dixon; John Hansen; David Mayer; Charlene McEvoy; Allison L. Naleway; Varsha Neelam; Caitlin Ray; Colin Rogerson; S. Bianca Salas; Tamara Sheffield; Lina S. Sy; Duck-Hye Yang; Ousseny Zerbo; Tara Curley; Kiran A. Faryar; Joanna Kramer; Jay Krishnan; Taylor Kristicevich; Aleda M. Leis; Amanda McKillop; Lora Nordstrom; Leah Odame-Bamfo; Ivana A. Vaughn; Emmanuel B. Walter; Elizabeth Wettick; Brianna M. Wickersham; Olivia L. Williams; Brian D. Williamson; Richard K. Zimmerman; Haris M. Ahmad; Christina Albertin; Vasanthi Avadhanula; James D. Chappell; Juliana DaSilva; Janet A. Englund; Megan C. Freeman; Lisa M. Keong; Eileen J. Klein; Mary E. Moffatt; Daniel C. Payne; Leila C. Sahni; Elizabeth P. Schlaudecker; Rangaraj Selvarangan; Laura S. Stewart; Peter G. Szilagyi; John V. Williams

PMC · DOI:10.15585/mmwr.mm7509a2·March 12, 2026

Interim Estimates of 2025–26 Seasonal Influenza Vaccine Effectiveness — United States, September 2025–February 2026

Patrick Maloney, Emily L. Reeves, Kristina Wielgosz, Ashley M. Price, Karthik Natarajan, Malini B. DeSilva, Kristin Dascomb, Nicola P. Klein, Sara Y. Tartof, Stephanie A. Irving, Shaun J. Grannis, Toan C. Ong, Zachary A. Weber, Jennifer E. Schuster, Danielle M. Zerr

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Abstract

Linked entities

Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.

Species2

H3N2 subtype(serotype)Homo sapiens(human · species)

Diseases2

influenza respiratory illness

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Taxonomy

TopicsInfluenza Virus Research Studies · Respiratory viral infections research · Virology and Viral Diseases