Cyclover-Assisted Liquid-Phase Peptide Synthesis Using T3P® as a Green Coupling Reagent
Priyanka Kushwaha, Marvin Mantel, Peter Talbiersky, Yongfu Li, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio
TL;DR
This paper introduces Cyclover, a tag that improves green and efficient liquid-phase peptide synthesis using T3P®.
Contribution
Cyclover enables tunable, sustainable LPPS with T3P® in 2Me-THF, reducing PMI while maintaining yield and purity.
Findings
Cyclover reduces PMI by ∼2.7-fold in LPPS.
T3P® maintains high purity and isolated yield in peptide synthesis.
The method offers a greener route for complex peptides.
Abstract
Liquid-phase peptide synthesis (LPPS) continues to evolve toward more sustainable and efficient methodologies. In this study, we introduce Cyclover as a tag that enables efficient, tunable LPPS in 2Me-THF using propylphosphonic anhydride (T3P®) as a coupling reagent. The extraction protocol reduces the PMI ∼2.7-fold while maintaining high purity and isolated yield, offering a greener and versatile route to complex peptides
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Taxonomy
TopicsChemical Synthesis and Analysis · Biochemical and Structural Characterization · Click Chemistry and Applications