Comprehensive Analysis Reveals Potential Molecular Targets in Juvenile Dermatomyositis
Chunyan Chen, Haifa Qiao
TL;DR
This study identifies 145 genes and regulatory elements linked to juvenile dermatomyositis, offering new insights into its molecular causes and potential treatments.
Contribution
The study provides a novel set of molecular targets and regulatory elements (TFs and miRNAs) associated with juvenile dermatomyositis.
Findings
145 genes were found to be significantly associated with juvenile dermatomyositis.
Key transcription factors and miRNAs, such as STAT1 and hsa-miR-127-3p, were identified as potential regulators in JDM.
Enriched biological processes include immune response and extracellular matrix organization.
Abstract
Juvenile dermatomyositis (JDM) is a rare autoimmune disease primarily affecting children, characterized by muscle weakness and skin lesions. This study identifies 145 genes significantly associated with JDM through differential gene expression analysis, weighted gene coexpression network analysis (WGCNA), protein–protein interaction network analysis, and miRNA and transcription factor (TF) prediction, using blood and muscle microarray sequencing datasets. Functional enrichment analysis indicates that these genes are involved in crucial biological processes, including cytokine‐mediated signaling, extracellular matrix organization, and immune response. Further analysis reveals key TFs (e.g., STAT1 and NFKB1) and miRNAs (e.g., hsa‐miR‐127‐3p and hsa‐miR‐17‐5p) that may regulate the expression of these critical genes in JDM. The findings provide new insights into the molecular mechanisms of…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsInflammatory Myopathies and Dermatomyositis · Spondyloarthritis Studies and Treatments · Caveolin-1 and cellular processes