Anti-Inflammatory Effect of Aniba rosaeodora Essential Oil-Loaded Chitosan Membrane
Bruna Michele A. de B. Buriti, Caio Augusto de Almeida Canelas, Venâncio A. Amaral, Laine Celestino Pinto, Renata C. Silva, William N. Setzer, Tais Gratieri, Pablo Luis B. Figueiredo, Marcele F. Passos, Joyce Kelly R. da Silva
TL;DR
This study shows that chitosan membranes infused with Aniba rosaeodora essential oil have anti-inflammatory properties and could be used as wound dressings.
Contribution
The novel contribution is the development of chitosan membranes with anti-inflammatory effects by incorporating Aniba rosaeodora essential oil.
Findings
ArEO incorporation increased thermal stability and prevented essential oil degradation.
Membranes with ArEO significantly reduced nitrite and TNF-α levels in inflammation models.
ArEO-loaded membranes maintained mechanical properties suitable for wound dressing applications.
Abstract
Bioactive chitosan (CH) membranes containing 0.5, 2.5, and 5.0% w/w of Aniba rosaeodora essential oil (ArEO), rich in linalool (82.9%) and cis-linalool oxide (2.9%) were developed using the casting method. Fourier transform infrared spectroscopy (FTIR) results demonstrated that CH chains interacted with ArEO, leading to increased thermal stability and preventing isolated ArEO degradation. ArEO concentrations did not influence membrane morphology. Incorporating ArEO into the formulated membranes did not significantly alter their Young’s modulus (41.84–48.00 MPa), which remains within the skin’s modulus of elasticity range (0.02 to 57 MPa). They also exhibited mucoadhesion for tissue adhesion, with no significant difference with adding ArEO (0.135–0.161 N). Additionally, ArEO incorporated into the developed wound dressings significantly reduced nitrite levels in the in vitro inflammation…
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Taxonomy
TopicsWound Healing and Treatments · Essential Oils and Antimicrobial Activity · Nanocomposite Films for Food Packaging