MMP‐8 in Peri‐Implantitis: A Cross‐Sectional Study on Genetic Polymorphisms and Enzymatic Activation
Ioannis Fragkioudakis, Christine Kottaridi, Michalis Paraskeva, Dimitra Sakellari
TL;DR
This study explores how a genetic variation in MMP-8 relates to increased protein activity and may help diagnose peri-implantitis.
Contribution
The study identifies a genetic polymorphism in MMP-8 linked to elevated active protein levels in peri-implantitis.
Findings
MMP-8 gene polymorphism (-799C/T) is associated with peri-implantitis.
Upregulated MMP-8 mRNA in peri-implant crevicular fluid correlates with disease.
Elevated active MMP-8 protein levels are independently linked to peri-implantitis.
Abstract
This graphical abstract illustrates a molecular cascade linking MMP‐8 gene polymorphism (−799C/T), upregulated mRNA expression in peri‐implant crevicular fluid, and elevated active MMP‐8 protein levels. These factors were independently associated with peri‐implantitis and may support molecular‐based diagnostics.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsProtease and Inhibitor Mechanisms · Oral microbiology and periodontitis research · Oral and gingival health research