# MMP‐8 in Peri‐Implantitis: A Cross‐Sectional Study on Genetic Polymorphisms and Enzymatic Activation

**Authors:** Ioannis Fragkioudakis, Christine Kottaridi, Michalis Paraskeva, Dimitra Sakellari

PMC · DOI: 10.1111/jre.70026 · 2025-08-07

## TL;DR

This study explores how a genetic variation in MMP-8 relates to increased protein activity and may help diagnose peri-implantitis.

## Contribution

The study identifies a genetic polymorphism in MMP-8 linked to elevated active protein levels in peri-implantitis.

## Key findings

- MMP-8 gene polymorphism (-799C/T) is associated with peri-implantitis.
- Upregulated MMP-8 mRNA in peri-implant crevicular fluid correlates with disease.
- Elevated active MMP-8 protein levels are independently linked to peri-implantitis.

## Abstract

This graphical abstract illustrates a molecular cascade linking MMP‐8 gene polymorphism (−799C/T), upregulated mRNA expression in peri‐implant crevicular fluid, and elevated active MMP‐8 protein levels. These factors were independently associated with peri‐implantitis and may support molecular‐based diagnostics.

## Linked entities

- **Genes:** MMP8 (matrix metallopeptidase 8) [NCBI Gene 4317]
- **Proteins:** MMP8 (matrix metallopeptidase 8)

## Full-text entities

- **Genes:** POTEF (POTE ankyrin domain family member F) [NCBI Gene 728378] {aka A26C1B, POTE2alpha, POTEACTIN}, MMP8 (matrix metallopeptidase 8) [NCBI Gene 4317] {aka CLG1, HNC, MMP-8, PMNL-CL}
- **Diseases:** PICF (MESH:D057873), mucositis (MESH:D052016), bone loss (MESH:D001847), bleeding (MESH:D006470), inflammation (MESH:D007249), periodontitis (MESH:D010518)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** -799C/T, +17C/G, -381A/G

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12961359/full.md

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Source: https://tomesphere.com/paper/PMC12961359