Fibroblast-Targeted Nanodelivery Systems: Mechanisms of Collagen Remodeling Regulation and Novel Strategies for Scar Repair
Junshan Lan, Zhipeng Teng, Qian Huang, Fang Qin, Yibin Zheng, Yuting Liu, Yilin Chang, Xing Zhou, Xiaohui Li, Wenwu Wan, Lu Wang, Jie Lou
TL;DR
This review explores how nanodelivery systems can target fibroblasts to regulate collagen remodeling and improve scar repair.
Contribution
The paper introduces a framework linking fibroblast biology and nanodelivery design for scar-minimizing therapies.
Findings
Fibroblast activation and differentiation into myofibroblasts drive excessive scar formation.
NDDSs can modulate fibroblast behavior through targeted delivery and stimuli-responsive designs.
Materials design should align with fibroblast states and wound-stage cues for effective scar repair.
Abstract
Scar formation is a common outcome of post-injury repair and can compromise both esthetic appearance and physiological function. Fibroblasts are central mediators of this process; their aberrant activation or differentiation into myofibroblasts drives fibrosis and excessive scar tissue accumulation. Nanodrug delivery systems (NDDSs) offer unique opportunities to modulate fibroblast behavior through cell-/microenvironment-guided targeting, controlled release, and stimuli-adaptive designs. Here, we summarize fibroblast biology across scar repair and delineate the mechanistic underpinnings of scar pathogenesis. We then synthesize recent progress in NDDS-enabled interventions for pathological scarring, with an emphasis on how materials design can be matched to fibroblast states and wound-stage cues. By connecting mechanisms to delivery strategies, this review provides a framework to guide…
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Taxonomy
TopicsWound Healing and Treatments · Periodontal Regeneration and Treatments · Silk-based biomaterials and applications