# Fibroblast-Targeted Nanodelivery Systems: Mechanisms of Collagen Remodeling Regulation and Novel Strategies for Scar Repair

## TL;DR

This review explores how nanodelivery systems can target fibroblasts to regulate collagen remodeling and improve scar repair.

## Contribution

The paper introduces a framework linking fibroblast biology and nanodelivery design for scar-minimizing therapies.

## Key findings

- Fibroblast activation and differentiation into myofibroblasts drive excessive scar formation.
- NDDSs can modulate fibroblast behavior through targeted delivery and stimuli-responsive designs.
- Materials design should align with fibroblast states and wound-stage cues for effective scar repair.

## Abstract

Scar formation is a common outcome of post-injury repair and can compromise both esthetic appearance and physiological function. Fibroblasts are central mediators of this process; their aberrant activation or differentiation into myofibroblasts drives fibrosis and excessive scar tissue accumulation. Nanodrug delivery systems (NDDSs) offer unique opportunities to modulate fibroblast behavior through cell-/microenvironment-guided targeting, controlled release, and stimuli-adaptive designs. Here, we summarize fibroblast biology across scar repair and delineate the mechanistic underpinnings of scar pathogenesis. We then synthesize recent progress in NDDS-enabled interventions for pathological scarring, with an emphasis on how materials design can be matched to fibroblast states and wound-stage cues. By connecting mechanisms to delivery strategies, this review provides a framework to guide the development of scar-minimizing therapies and functional tissue regeneration.