Characterization of a Novel Cyclized Prodigiosin Derivative from Termite Mound-Associated Streptomyces and Its Potential in Cosmetic Applications
Pisit Poolprasert, Tawatchai Sumpradit, Kanjana Wongkrajang, Katekan Dajanta, Sittichai Urtgam, Chaowalit Puengtang, Naruemol Thurnkul
TL;DR
A new pink pigment from termite mound bacteria shows antibacterial and antioxidant properties, making it promising for cosmetics.
Contribution
The first report of a novel cyclized prodigiosin derivative from termite-associated Streptomyces with potential cosmetic applications.
Findings
A novel cyclized prodigiosin derivative (C36H46N4O5) was identified from a Streptomyces strain in termite mounds.
The pigment showed strong antibacterial activity against Gram-positive bacteria and antioxidant properties.
The pigment was stable in cosmetic formulations, indicating industrial feasibility.
Abstract
Termite mounds are rich, underexplored reservoirs of bioactive Streptomyces. This study focuses on the isolation and metabolic characterization of pigment-producing Streptomyces from Macrotermes gilvus mounds in Thailand. Four pigment-producing strains related to S. violarus, S. aureofaciens, S. roseoverticillatus, and S. flavofungini were analyzed. These strains exhibited robust antibacterial properties, primarily against Gram-positive bacteria, and significant antioxidant capacity. Structural elucidation using HRMS and NMR identified a stable pink pigment from strain A2 as a novel cyclized prodigiosin derivative (C36H46N4O5). To our knowledge, this is the first report of a novel prodiginine sourced from termite-associated actinobacteria. Feasibility trials in cosmetic formulations confirmed the pigment’s stability, suggesting significant potential for industrial use. These results…
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Taxonomy
TopicsMicrobial Metabolism and Applications · Microbial Natural Products and Biosynthesis · Biochemical and biochemical processes