The LDL pathway regulates actomyosin ring dynamics necessary for optimal cell wound repair

TL;DR

This study shows that the LDL pathway helps cells repair wounds by regulating the actomyosin ring, which is crucial for closing the wound.

Contribution

The LDL pathway's role in actomyosin ring formation during cell wound repair is newly identified.

Findings

The LDL pathway is essential for robust actomyosin ring formation during cell wound repair.

This pathway plays an unexpected role in regulating actin dynamics necessary for wound closure.

Abstract

Individual cells must rapidly repair any cortical damage from environmental or physiological stresses, to survive and to contribute to maintaining the proper function of tissues and organs. The formation of an actomyosin ring around the wound periphery is an important step in physically closing the cell wound. Here, we find that the Low-Density Lipoprotein (LDL) pathway, which is usually associated with plasma membrane homeostasis, is needed for optimal cell wound repair. In this context, the LDL pathway is required for robust actomyosin ring formation, revealing an unexpected role in regulating actin dynamics during cell wound repair.

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