Calcium-binding proteins as allergens
Andrea O'Malley, Kriti Khatri, Elaine M. Wright, Rebekka A. Pittsley, Krzysztof Kowal, Maksymilian Chruszcz
TL;DR
This review explores calcium-binding proteins that act as allergens, causing both inhaled and food allergies.
Contribution
The paper reviews various calcium-binding protein families that are allergenic and their roles in allergic reactions.
Findings
Calcium-binding proteins like parvalbumin and troponin C are common allergens.
These allergens show significant IgE reactivity and cross-reactivity.
They are difficult to avoid due to their widespread presence in nature.
Abstract
Calcium-binding proteins, particularly those in the EF-hand family, are found ubiquitously in nature, primarily for calcium transport and storage in the body. In this review, we discuss allergens in the parvalbumin, polcalcin, sarcoplasmic calcium-binding protein, and troponin C families, as well as additional allergens. Allergens from these protein families display a wide range of IgE reactivity and cross-reactivity. They are implicated in both inhaled and food allergies, and, due to their common presence, they are difficult to avoid.
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Taxonomy
TopicsFood Allergy and Anaphylaxis Research · Asthma and respiratory diseases · Occupational exposure and asthma