# Calcium-binding proteins as allergens

## TL;DR

This review explores calcium-binding proteins that act as allergens, causing both inhaled and food allergies.

## Contribution

The paper reviews various calcium-binding protein families that are allergenic and their roles in allergic reactions.

## Key findings

- Calcium-binding proteins like parvalbumin and troponin C are common allergens.
- These allergens show significant IgE reactivity and cross-reactivity.
- They are difficult to avoid due to their widespread presence in nature.

## Abstract

Calcium-binding proteins, particularly those in the EF-hand family, are found ubiquitously in nature, primarily for calcium transport and storage in the body. In this review, we discuss allergens in the parvalbumin, polcalcin, sarcoplasmic calcium-binding protein, and troponin C families, as well as additional allergens. Allergens from these protein families display a wide range of IgE reactivity and cross-reactivity. They are implicated in both inhaled and food allergies, and, due to their common presence, they are difficult to avoid.