CFD Mechanistic Modeling of a Monolithic Chromatography System: Challenges and Opportunities
Jamille Coelho Coimbra, Diego Martinez Prata, Raquel Nunes Fernandes, Marcio Arêdes Martins, Luis Antonio Minim
TL;DR
This paper reviews how computer modeling can improve monolithic chromatography systems for better separation efficiency.
Contribution
The paper introduces computer-aided engineering to model and modify monolithic chromatography structures.
Findings
Current models lack detailed morphology integration.
Computer-aided engineering can enhance separation efficiency.
Mathematical models and porous geometries are evolving for chromatography.
Abstract
Monolithic chromatographic supports are part of the fourth generation of chromatographic separation media. A comprehensive knowledge of the transport phenomena described by mechanistic models is important for the purposes of project design for meeting regulatory requirements and optimizing production. Although geometric characteristics influence monolithic support properties, few approaches have incorporated morphology details into the models. Thus, there is a gap for new model developments in complex porous matrices, which may be alternatives to the more classic phenomenological approaches. This review differs from those previously published by demonstrating the utilization of computer-aided engineering to enhance the construction and modification of channel microstructures for the purpose of achieving more effective separation, integrating mathematical models, and constructing porous…
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Taxonomy
TopicsProtein purification and stability · Analytical Chemistry and Chromatography · Microfluidic and Capillary Electrophoresis Applications