# CFD Mechanistic Modeling of a Monolithic Chromatography System: Challenges and Opportunities

## TL;DR

This paper reviews how computer modeling can improve monolithic chromatography systems for better separation efficiency.

## Contribution

The paper introduces computer-aided engineering to model and modify monolithic chromatography structures.

## Key findings

- Current models lack detailed morphology integration.
- Computer-aided engineering can enhance separation efficiency.
- Mathematical models and porous geometries are evolving for chromatography.

## Abstract

Monolithic chromatographic supports are part of the fourth
generation
of chromatographic separation media. A comprehensive knowledge of
the transport phenomena described by mechanistic models is important
for the purposes of project design for meeting regulatory requirements
and optimizing production. Although geometric characteristics influence
monolithic support properties, few approaches have incorporated morphology
details into the models. Thus, there is a gap for new model developments
in complex porous matrices, which may be alternatives to the more
classic phenomenological approaches. This review differs from those
previously published by demonstrating the utilization of computer-aided
engineering to enhance the construction and modification of channel
microstructures for the purpose of achieving more effective separation,
integrating mathematical models, and constructing porous geometries.
This work presents the status quo evolution of mathematical models
and also presents the trends, challenges, and opportunities.