Comprehensive analysis of COLGALT1 in tumor microenvironment regulation and prognosis of clear cell renal cell carcinoma
Yicheng Guo, Bin Wang, Guixin Ding, Yanwei Zhang, Yini Wang, Xiaohong Ma, Jitao Wu
TL;DR
This study explores the role of COLGALT1 in clear cell renal cell carcinoma, finding it linked to immune cell infiltration and a potential biomarker for prognosis.
Contribution
The study identifies COLGALT1 as a novel prognostic biomarker and potential therapeutic target in ccRCC.
Findings
COLGALT1 expression is significantly upregulated in ccRCC at both mRNA and protein levels.
COLGALT1 correlates with infiltration of monocytes, T helper 2 cells, macrophages, regulatory T cells, and natural killer cells.
COLGALT1 is strongly associated with M2 macrophage markers, indicating a role in immunosuppressive tumor environments.
Abstract
Collagen galactosyltransferase 1 (COLGALT1), a key enzyme involved in collagen post-translational modification, has been implicated in extracellular matrix remodeling across multiple cancer types, yet its prognostic significance and relationship with the tumor immune microenvironment in clear cell renal cell carcinoma (ccRCC) remain unclear. In this study, we analyzed multi-omics datasets from public repositories to assess COLGALT1 expression patterns, clinical relevance, and prognostic value in ccRCC. Quantitative real-time PCR was performed to validate its expression in renal cancer cell lines and normal renal tubular epithelial cells. Immune infiltration profiles were characterized using multiple computational algorithms, and a competing endogenous RNA network was constructed to explore regulatory mechanisms. Our results demonstrated that COLGALT1 expression was significantly…
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Taxonomy
TopicsFerroptosis and cancer prognosis · Cell Adhesion Molecules Research · Renal cell carcinoma treatment