Unraveling the Complexity of Celiac Disease: A Narrative Review of Its Multisystem Nature
Maria Rogalidou, Dimitrios Christodoulou
TL;DR
This review explores celiac disease as a complex, multisystem disorder beyond the gut, emphasizing its varied symptoms and new treatment approaches.
Contribution
The paper provides a narrative review highlighting recent insights into celiac disease's pathogenesis and emerging therapies.
Findings
Celiac disease is now recognized as a multisystem disorder with diverse clinical presentations.
Recent insights include genetic predisposition, immune mechanisms, and environmental factors in celiac disease.
Emerging therapies aim to improve patient outcomes and reduce reliance on gluten-free diets.
Abstract
Celiac disease is a chronic immune-mediated disorder triggered by the ingestion of gluten in genetically susceptible individuals, primarily those carrying HLA-DQ2 or HLA-DQ8 and, in rare cases, HLA DQ7 alleles. Although traditionally regarded as a gastrointestinal condition, celiac disease is now recognized as a multisystem disorder with a wide range of clinical presentations. It has been described as a “clinical chameleon” due to its variable manifestations, which may include non-specific symptoms, extraintestinal involvement, or even an asymptomatic course, often identified only through screening of high-risk groups. This narrative review provides a comprehensive overview of celiac disease, highlighting recent insights into its pathogenesis, including genetic predisposition, immune mechanisms, and the role of environmental and microbial factors. It emphasizes the importance of…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsCeliac Disease Research and Management · Microscopic Colitis · Microbial Metabolites in Food Biotechnology