# Unraveling the Complexity of Celiac Disease: A Narrative Review of Its Multisystem Nature

## TL;DR

This review explores celiac disease as a complex, multisystem disorder beyond the gut, emphasizing its varied symptoms and new treatment approaches.

## Contribution

The paper provides a narrative review highlighting recent insights into celiac disease's pathogenesis and emerging therapies.

## Key findings

- Celiac disease is now recognized as a multisystem disorder with diverse clinical presentations.
- Recent insights include genetic predisposition, immune mechanisms, and environmental factors in celiac disease.
- Emerging therapies aim to improve patient outcomes and reduce reliance on gluten-free diets.

## Abstract

Celiac disease is a chronic immune-mediated disorder triggered by the ingestion of gluten in genetically susceptible individuals, primarily those carrying HLA-DQ2 or HLA-DQ8 and, in rare cases, HLA DQ7 alleles. Although traditionally regarded as a gastrointestinal condition, celiac disease is now recognized as a multisystem disorder with a wide range of clinical presentations. It has been described as a “clinical chameleon” due to its variable manifestations, which may include non-specific symptoms, extraintestinal involvement, or even an asymptomatic course, often identified only through screening of high-risk groups. This narrative review provides a comprehensive overview of celiac disease, highlighting recent insights into its pathogenesis, including genetic predisposition, immune mechanisms, and the role of environmental and microbial factors. It emphasizes the importance of recognizing extraintestinal features, outlines current diagnostic approaches and their limitations, and discusses management strategies centered around the gluten-free diet. Furthermore, it explores emerging therapies aimed at improving patient outcomes and reducing dependence on dietary restriction. By synthesizing the latest developments, this review aims to present a fresh perspective on a condition with significant clinical relevance that is evolving.