Development of Human Serum Albumin-Based Hydrogels for Potential Use as Wound Dressings
Inna Zharkova, Irina Bauer, Oksana Gulyaeva, Evgenia Kozyreva, Zhanna Nazarkina, Elena Dmitrienko
TL;DR
This paper introduces a new method to create wound dressings using human serum albumin hydrogels that can release antibiotics and fight bacteria.
Contribution
The first development of HSA-based hydrogels using thermal- and ethanol-induced methods for wound management.
Findings
HSA-based hydrogels can be fabricated with tunable properties using PBS and limited ethanol.
The hydrogels showed antibacterial activity against multiple bacterial strains when loaded with tetracycline.
They demonstrated structural stability, biocompatibility, and biodegradability in physiological conditions.
Abstract
Protein-based materials such as human serum albumin (HSA) have demonstrated significant potential for the development of novel wound management materials. For the first time, the formation of HSA-based hydrogels was proposed using a combination of thermal- and ethanol-induced approaches. The combination of phosphate-buffered saline (PBS) and limited (up to 20% v/v) ethanol content offers a promising strategy for fabricating human serum albumin-based hydrogels with tunable properties. The hydrogel formation was studied using in situ dynamic light scattering (DLS) for qualitative and semi-quantitative analysis of the patterns of protein hydrogel formation through thermally induced gelation. The rheological properties of human serum albumin-based hydrogels were investigated. Hydrogels synthesized via thermally induced gelation using a denaturing agent exhibit a dynamic viscosity ranging…
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Taxonomy
TopicsWound Healing and Treatments · Hydrogels: synthesis, properties, applications · Polymer Surface Interaction Studies