The Botucatu Document: One health antifungal resistance policies — A call for action
Paulo Cezar Ceresini, Waldir Cintra de Jesus Junior, Ana Carolina Firmino, Bárbara Pereira Christofaro Silva, Danilo Tancler Stipp, Edson Luiz Furtado, Fábio Luiz Checchio Mingotte, Karine Assis Costa, Paulo Renato Matos Lopes, Rita Luiza Peruquetti

TL;DR
Experts in Brazil created a unified plan to combat antifungal resistance in fungi like Aspergillus fumigatus by integrating health, agriculture, and environmental sectors.
Contribution
The Botucatu Document introduces a One Health policy framework for antifungal resistance in Brazil, emphasizing cross-sector collaboration and governance.
Findings
The Botucatu Document outlines coordinated national actions for antifungal resistance in Brazil.
It emphasizes the need for environmental aerobiome surveillance and fungicide regulation.
The document promotes FAIR data transparency and cross-sector governance for AMR.
Abstract
Antifungal resistance in Aspergillus fumigatus and other environmental fungi represents a growing global threat to human health, driven in part by agricultural fungicide use. The scale of the threat is masked by inadequate multisector surveillance. In December 2025, the Brazilian Network Meeting on Aspergillus fumigatus Antimicrobial Resistance convened clinical, agricultural, environmental, and public-health experts to address these challenges using a One Health framework. Through a structured plenary deliberation, participants approved “The Botucatu Document: One Health Antifungal Resistance Policies — A Call for Action,” a unified Public Statement of Concern outlining governance principles and coordinated national actions for Brazil. The Statement reflects consensus across four Working Groups on clinical surveillance, environmental monitoring, fungicide regulation, and public health…
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Taxonomy
TopicsAntifungal resistance and susceptibility · Mycotoxins in Agriculture and Food · Infectious Diseases and Mycology
