Gamma irradiation crosslinked fluorescent nanocarbon based biodegradable hydrogel for controlled release of antibiotics
Rajeshwar Vodeti, Mokhtar Rejili, Venkata Ramana Singamaneni, Umme Hani, Farhat Fatima, Jeetendra Kumar Gupta, Patibandla Jahnavi, Ramenani Hari Babu, Sharuk L. Khan, Md. Faysal
TL;DR
A new biodegradable hydrogel using fluorescent carbon dots is developed for controlled antibiotic release and real-time monitoring.
Contribution
A gamma-irradiated hydrogel with fluorescent carbon dots enables controlled drug release and real-time monitoring.
Findings
Fluorescent carbon dots enhance mechanical stability and enable real-time monitoring of hydrogel degradation.
Drug release is reduced from 70% to 40% with carbon dots, allowing precise control.
Gamma irradiation allows simultaneous crosslinking and sterilization in a single step.
Abstract
Controlled and sustained antibiotic delivery is critical for combating antimicrobial resistance while minimizing side effects. Herein, a novel biodegradable hydrogel system, synthesized via gamma irradiation, incorporating fluorescent carbon dots (CDs) as multifunctional nano-crosslinkers, has been reported. The CDs, prepared from sustainable bio-precursors, reinforced the polymer network and enhanced the mechanical stability and swelling behavior, while simultaneously serving as intrinsic fluorescent probes for potential real-time monitoring of degradation and drug release. Thorough characterization revealed consistent morphology, adjustable biodegradability, and enhanced rheological characteristics. Drug release investigations demonstrated a diffusion-controlled mechanism, wherein the integration of CD diminished the cumulative antibiotic release from approximately 70% to…
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Taxonomy
TopicsHydrogels: synthesis, properties, applications · Carbon and Quantum Dots Applications · Advanced Cellulose Research Studies