Draft whole-genome sequences of ancestral and modern Mycobacterium tuberculosis Beijing strains with different patterns of virulence
Lia Gomes, Edson Machado, Michel Abanto Marin, Sidra Vasconcellos, Antonio Basílio de Miranda, Igor Mokrousov, Elena Lasunskaia, Philip Suffys
TL;DR
This paper presents the full genome sequences of modern and ancient tuberculosis strains from different countries to study their virulence differences.
Contribution
The study provides new whole-genome sequences of Mycobacterium tuberculosis Beijing strains from diverse geographic regions.
Findings
Genomes of modern and ancient sublineage strains were sequenced from Brazil, Mozambique, and Russia.
The study compares virulence patterns between the two sublineages of M. tuberculosis.
Abstract
Mycobacterium tuberculosis of the Beijing Modern Sublineage displays increased virulence when compared with strains of the Ancient Sublineage. Here, we report the full genome of strains of the two sublineages isolated from tuberculosis patients from Brazil, Mozambique, and Russia.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsTuberculosis Research and Epidemiology · Mycobacterium research and diagnosis · Diagnosis and treatment of tuberculosis