# Draft whole-genome sequences of ancestral and modern Mycobacterium tuberculosis Beijing strains with different patterns of virulence

**Authors:** Lia Gomes, Edson Machado, Michel Abanto Marin, Sidra Vasconcellos, Antonio Basílio de Miranda, Igor Mokrousov, Elena Lasunskaia, Philip Suffys

PMC · DOI: 10.1128/mra.00211-25 · 2025-12-12

## TL;DR

This paper presents the full genome sequences of modern and ancient tuberculosis strains from different countries to study their virulence differences.

## Contribution

The study provides new whole-genome sequences of Mycobacterium tuberculosis Beijing strains from diverse geographic regions.

## Key findings

- Genomes of modern and ancient sublineage strains were sequenced from Brazil, Mozambique, and Russia.
- The study compares virulence patterns between the two sublineages of M. tuberculosis.

## Abstract

Mycobacterium tuberculosis of the Beijing Modern Sublineage displays increased virulence when compared with strains of the Ancient Sublineage. Here, we report the full genome of strains of the two sublineages isolated from tuberculosis patients from Brazil, Mozambique, and Russia.

## Linked entities

- **Diseases:** tuberculosis (MONDO:0018076)
- **Species:** Mycobacterium tuberculosis (taxon 1773)

## Full-text entities

- **Diseases:** tuberculosis (MESH:D014376)
- **Species:** Mycobacterium tuberculosis (species) [taxon 1773], Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC12797994