Real-world evaluation of ceftriaxone-related safety events: a stewardship call to action

TL;DR

This study evaluated ceftriaxone safety in real-world use and found few serious adverse events, similar to other cephalosporins.

Contribution

The study provides real-world evidence on ceftriaxone safety, addressing a recent safety alert with large-scale data.

Findings

Ceftriaxone-related adverse events were rare despite high usage.

Event rates were similar to other intravenous cephalosporins.

Findings support continued cautious use of ceftriaxone.

Abstract

A ceftriaxone safety alert prompted a review of rapid response and cardiac arrest events in relation to the timing of intravenous cephalosporin administrations across a large health system. Despite high utilization, we found a low rate of significant ceftriaxone-related adverse events with a similar incidence as other intravenous cephalosporins.

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