# Real-world evaluation of ceftriaxone-related safety events: a stewardship call to action

## TL;DR

This study evaluated ceftriaxone safety in real-world use and found few serious adverse events, similar to other cephalosporins.

## Contribution

The study provides real-world evidence on ceftriaxone safety, addressing a recent safety alert with large-scale data.

## Key findings

- Ceftriaxone-related adverse events were rare despite high usage.
- Event rates were similar to other intravenous cephalosporins.
- Findings support continued cautious use of ceftriaxone.

## Abstract

A ceftriaxone safety alert prompted a review of rapid response and cardiac arrest events in relation to the timing of intravenous cephalosporin administrations across a large health system. Despite high utilization, we found a low rate of significant ceftriaxone-related adverse events with a similar incidence as other intravenous cephalosporins.