Acute Spinal Cord Injury in the Setting of C6 Pathologic Fracture Secondary to Metastatic Paraganglioma: A Case Report and Review of Literature
Arshi Kaur, Sarah Danehower, Hannah G Rupp, Ramin Hamidi, Mercia J Bezerra Gondim, Thomas Altstadt

TL;DR
A rare case of a spinal injury caused by a metastatic tumor in a young man is reported, highlighting an unusual medical scenario.
Contribution
This case report documents a rare instance of metastatic paraganglioma causing cervical spine fracture and spinal cord injury.
Findings
A 25-year-old male developed a C6 pathologic fracture from metastatic paraganglioma.
The patient experienced acute spinal cord injury and neurogenic shock requiring urgent treatment.
Metastatic involvement of the cervical spine from paraganglioma is exceptionally uncommon.
Abstract
Paragangliomas (PG) are rare extra-adrenal neuroendocrine tumors that arise from neural crest-derived chromaffin cells. Metastatic involvement of the spine, particularly in the cervical region, is exceptionally uncommon. Here, we present an exceedingly rare case of a 25-year-old male with metastatic spread from a recurrent functional aortocaval paraganglioma to the cervical spine, ultimately leading to a pathological fracture, acute spinal cord injury, and neurogenic shock requiring urgent intervention.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsAdrenal and Paraganglionic Tumors · Management of metastatic bone disease · Pituitary Gland Disorders and Treatments
