# Acute Spinal Cord Injury in the Setting of C6 Pathologic Fracture Secondary to Metastatic Paraganglioma: A Case Report and Review of Literature

**Authors:** Arshi Kaur, Sarah Danehower, Hannah G Rupp, Ramin Hamidi, Mercia J Bezerra Gondim, Thomas Altstadt

PMC · DOI: 10.7759/cureus.98403 · 2025-12-03

## TL;DR

A rare case of a spinal injury caused by a metastatic tumor in a young man is reported, highlighting an unusual medical scenario.

## Contribution

This case report documents a rare instance of metastatic paraganglioma causing cervical spine fracture and spinal cord injury.

## Key findings

- A 25-year-old male developed a C6 pathologic fracture from metastatic paraganglioma.
- The patient experienced acute spinal cord injury and neurogenic shock requiring urgent treatment.
- Metastatic involvement of the cervical spine from paraganglioma is exceptionally uncommon.

## Abstract

Paragangliomas (PG) are rare extra-adrenal neuroendocrine tumors that arise from neural crest-derived chromaffin cells. Metastatic involvement of the spine, particularly in the cervical region, is exceptionally uncommon. Here, we present an exceedingly rare case of a 25-year-old male with metastatic spread from a recurrent functional aortocaval paraganglioma to the cervical spine, ultimately leading to a pathological fracture, acute spinal cord injury, and neurogenic shock requiring urgent intervention.

## Linked entities

- **Diseases:** paraganglioma (MONDO:0000448), spinal cord injury (MONDO:0043797)

## Full-text entities

- **Diseases:** extra-adrenal neuroendocrine tumors (MESH:D018358), PG (MESH:D010235), Fracture (MESH:D050723), neurogenic shock (MESH:D012769), Spinal Cord Injury (MESH:D013119)

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12765197/full.md

---
Source: https://tomesphere.com/paper/PMC12765197