New Insights into Potential Anti-Aging and Fatigue Effects of a Dietary Supplement from the Resveratrol Beverage in Aged SAMP8 Mice

TL;DR

This study shows that a resveratrol-rich beverage can reduce fatigue and signs of aging in aged mice by improving physical performance and brain function.

Contribution

The study demonstrates that long-term resveratrol supplementation improves anti-aging and anti-fatigue effects in aged SAMP8 mice.

Findings

Medium- and high-dose resveratrol groups showed improved locomotion and grip strength.

Resveratrol reduced aging indices and improved learning and memory in SAMP8 mice.

Liver antioxidant activity increased and brain peroxide levels decreased in resveratrol groups.

Abstract

This study investigated the anti-fatigue and anti-aging benefits of continuous intake of resveratrol (RES)-rich beverages. Locomotion and forelimb grip strength performance were significantly improved in medium- and high-dose RES groups. In terms of aging indices, the scores for the medium- and high-dose groups were significantly lower than those of the control group. In the PAT and active shuttle avoidance tests, the three RES groups performed better than the control group. A significant increase in SOD and catalase activity in the liver and a reduction in TBARS and 8-OHdG levels in the brain were observed in the medium- and high-dose groups. Thus, supplementation with RES-rich beverages for 13 weeks significantly improved fatigue, locomotor performance, learning and memory abilities, and liver antioxidant activity and reduced brain peroxide levels in SAMP8 mice.

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