# New Insights into Potential Anti-Aging and Fatigue Effects of a Dietary Supplement from the Resveratrol Beverage in Aged SAMP8 Mice

## TL;DR

This study shows that a resveratrol-rich beverage can reduce fatigue and signs of aging in aged mice by improving physical performance and brain function.

## Contribution

The study demonstrates that long-term resveratrol supplementation improves anti-aging and anti-fatigue effects in aged SAMP8 mice.

## Key findings

- Medium- and high-dose resveratrol groups showed improved locomotion and grip strength.
- Resveratrol reduced aging indices and improved learning and memory in SAMP8 mice.
- Liver antioxidant activity increased and brain peroxide levels decreased in resveratrol groups.

## Abstract

This study investigated the anti-fatigue and anti-aging benefits of continuous intake of resveratrol (RES)-rich beverages. Locomotion and forelimb grip strength performance were significantly improved in medium- and high-dose RES groups. In terms of aging indices, the scores for the medium- and high-dose groups were significantly lower than those of the control group. In the PAT and active shuttle avoidance tests, the three RES groups performed better than the control group. A significant increase in SOD and catalase activity in the liver and a reduction in TBARS and 8-OHdG levels in the brain were observed in the medium- and high-dose groups. Thus, supplementation with RES-rich beverages for 13 weeks significantly improved fatigue, locomotor performance, learning and memory abilities, and liver antioxidant activity and reduced brain peroxide levels in SAMP8 mice.