Cobalt-Catalyzed Four-Component Carbonylative Synthesis of γ‑Thioesters and γ‑Thioamides from Thioethers and Ethylene

TL;DR

A new cobalt-catalyzed method enables efficient synthesis of γ-thioesters and γ-thioamides using thioethers, ethylene, and nucleophiles.

Contribution

A novel cobalt-catalyzed four-component carbonylation method for synthesizing γ-thioether amides and esters is introduced.

Findings

The reaction demonstrates a broad substrate scope and good chemo- and regioselectivity.

It exhibits excellent functional-group tolerance.

The method provides an efficient route for alkene functionalization.

Abstract

Multicomponent carbonylative reactions have proven to
be indispensable
for constructing heterocycles and highly functionalized molecular
frameworks and represent an attractive strategy for alkene functionalization.
Herein, we report a cobalt-catalyzed four-component carbonylation
of thioethers and ethylene gas with diverse nucleophiles, affording
a series of γ-thioether amides and γ-thioether esters.
The reaction features a broad substrate scope, good chemo- and regioselectivity,
and excellent functional-group tolerance.

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