# Cobalt-Catalyzed Four-Component Carbonylative Synthesis of γ‑Thioesters and γ‑Thioamides from Thioethers and Ethylene

## TL;DR

A new cobalt-catalyzed method enables efficient synthesis of γ-thioesters and γ-thioamides using thioethers, ethylene, and nucleophiles.

## Contribution

A novel cobalt-catalyzed four-component carbonylation method for synthesizing γ-thioether amides and esters is introduced.

## Key findings

- The reaction demonstrates a broad substrate scope and good chemo- and regioselectivity.
- It exhibits excellent functional-group tolerance.
- The method provides an efficient route for alkene functionalization.

## Abstract

Multicomponent carbonylative reactions have proven to
be indispensable
for constructing heterocycles and highly functionalized molecular
frameworks and represent an attractive strategy for alkene functionalization.
Herein, we report a cobalt-catalyzed four-component carbonylation
of thioethers and ethylene gas with diverse nucleophiles, affording
a series of γ-thioether amides and γ-thioether esters.
The reaction features a broad substrate scope, good chemo- and regioselectivity,
and excellent functional-group tolerance.