Antineutrophil Cytoplasmic Antibody (ANCA) Vasculitis, Fatigue, and Treatment With Avacopan: A Case Series

TL;DR

This case series reports three patients with ANCA vasculitis who experienced increased fatigue during avacopan treatment, which improved after stopping the drug.

Contribution

The study highlights a potential side effect of avacopan related to fatigue in ANCA vasculitis patients.

Findings

Three patients experienced worsening fatigue after starting avacopan treatment.

Fatigue improved shortly after discontinuing avacopan.

Patients showed a good response to vasculitis treatment despite fatigue issues.

Abstract

This report describes three patients who developed marked somnolence and fatigue during treatment with avacopan for antineutrophil cytoplasmic antibody (ANCA) vasculitis. Though fatigue is a common symptom in ANCA vasculitis, each of these patients reported noticeable worsening of fatigue after starting avacopan, with improvement shortly after stopping the medication. All of them had a good response to treatment of their underlying vasculitis, and none of them had other clear causes of worsening fatigue.