# Antineutrophil Cytoplasmic Antibody (ANCA) Vasculitis, Fatigue, and Treatment With Avacopan: A Case Series

## TL;DR

This case series reports three patients with ANCA vasculitis who experienced increased fatigue during avacopan treatment, which improved after stopping the drug.

## Contribution

The study highlights a potential side effect of avacopan related to fatigue in ANCA vasculitis patients.

## Key findings

- Three patients experienced worsening fatigue after starting avacopan treatment.
- Fatigue improved shortly after discontinuing avacopan.
- Patients showed a good response to vasculitis treatment despite fatigue issues.

## Abstract

This report describes three patients who developed marked somnolence and fatigue during treatment with avacopan for antineutrophil cytoplasmic antibody (ANCA) vasculitis. Though fatigue is a common symptom in ANCA vasculitis, each of these patients reported noticeable worsening of fatigue after starting avacopan, with improvement shortly after stopping the medication. All of them had a good response to treatment of their underlying vasculitis, and none of them had other clear causes of worsening fatigue.