Influence of serum uric acid on bone mineral density across body mass index categories in men with type 2 diabetes: a cross-sectional study

TL;DR

This study finds that serum uric acid levels affect bone mineral density in older men with type 2 diabetes, but the effect depends on their body mass index.

Contribution

The study reveals how serum uric acid influences bone health differently across BMI categories in men with type 2 diabetes.

Findings

SUA was significantly associated with total lumbar BMD in men with BMI 24–27.999 kg/m².

Optimal SUA levels for bone health varied by BMI group, with 360–419 μmol/L being most beneficial for the 24–27.999 kg/m² group.

No significant correlation was found between SUA and femoral neck or total hip BMD.

Abstract

The impact of different serum uric acid(SUA) concentrations on bone mineral density(BMD) varied across different BMI categories, which might provide useful insights for clinical uric acid-lowering treatments.

To explore whether SUA was associated BMD across BMI categories in men aged ≥ 50 years with type 2 diabetes (T2D).

The participants were divided into six groups according to SUA levels. Analyses were adjusted for the covariates including weight(Wt), total lean mass(TLM), total fat mass(TFM), total fat ratio(TFr), A/G and a range of other baseline laboratory findings.

SUA was associated with total lumbar BMD(TLBMD) (p = 0.013). In the BMI(24–27.999 kg/m2) group, SUA was significantly associated with TLBMD (p = 0.02). There was no correlation between SUA and whole-body BMD, as well as femoral neck BMD and total hip BMD. In the BMI < 24 kg/m2 group, the highest TLBMD value was observed when SUA levels ranged from 420 µmol/L to 479 µmol/L. While BMI:24–27.999 kg/m2, the highest TLBMD value was showed in the SUA(360-419 μmol/L) group based on adjusted models. The SUA(300-360 μmol/L) group exhibited the highest TLBMD value among the patients with BMI ≥ 28 kg/m2.

SUA was correlated with TLBMD in T2D men aged ≥ 50 years. Among patients with BMI 24–27.999 kg/m2, the SUA concentrations between 360–419 μmol/L might have a protective effect on TLBMD.

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