# Influence of serum uric acid on bone mineral density across body mass index categories in men with type 2 diabetes: a cross-sectional study

## TL;DR

This study finds that serum uric acid levels affect bone mineral density in older men with type 2 diabetes, but the effect depends on their body mass index.

## Contribution

The study reveals how serum uric acid influences bone health differently across BMI categories in men with type 2 diabetes.

## Key findings

- SUA was significantly associated with total lumbar BMD in men with BMI 24–27.999 kg/m².
- Optimal SUA levels for bone health varied by BMI group, with 360–419 μmol/L being most beneficial for the 24–27.999 kg/m² group.
- No significant correlation was found between SUA and femoral neck or total hip BMD.

## Abstract

The impact of different serum uric acid(SUA) concentrations on bone mineral density(BMD) varied across different BMI categories, which might provide useful insights for clinical uric acid-lowering treatments.

To explore whether SUA was associated BMD across BMI categories in men aged ≥ 50 years with type 2 diabetes (T2D).

The participants were divided into six groups according to SUA levels. Analyses were adjusted for the covariates including weight(Wt), total lean mass(TLM), total fat mass(TFM), total fat ratio(TFr), A/G and a range of other baseline laboratory findings.

SUA was associated with total lumbar BMD(TLBMD) (p = 0.013). In the BMI(24–27.999 kg/m2) group, SUA was significantly associated with TLBMD (p = 0.02). There was no correlation between SUA and whole-body BMD, as well as femoral neck BMD and total hip BMD. In the BMI < 24 kg/m2 group, the highest TLBMD value was observed when SUA levels ranged from 420 µmol/L to 479 µmol/L. While BMI:24–27.999 kg/m2, the highest TLBMD value was showed in the SUA(360-419 μmol/L) group based on adjusted models. The SUA(300-360 μmol/L) group exhibited the highest TLBMD value among the patients with BMI ≥ 28 kg/m2.

SUA was correlated with TLBMD in T2D men aged ≥ 50 years. Among patients with BMI 24–27.999 kg/m2, the SUA concentrations between 360–419 μmol/L might have a protective effect on TLBMD.