Unlocking Mangiferin: A Therapeutic Candidate Revolutionizing Liver Disease Therapy
Jihang Xie, Sijing Su, Jianfa Wu, Xing Yang, Qian Zhang, Xiaojiang Shen, Linlin Zhao, Ting Wang, Nana Feng, Jinsong Su, Yi Zhang
TL;DR
Mangiferin, a natural antioxidant found in fruits and herbs, shows promise as a new therapy for liver diseases due to its ability to reduce oxidative stress.
Contribution
This review systematically explores mangiferin's properties, synthesis, bioavailability, and mechanisms in liver disease treatment.
Findings
Mangiferin exhibits potent antioxidative effects crucial for liver disease mitigation.
The compound shows hepatoprotective properties and potential for clinical application.
Strategies to enhance mangiferin's bioavailability are discussed for improved therapeutic outcomes.
Abstract
Mangiferin (MF), a natural component widely found in fruits, vegetables, and herbs, has garnered increasing attention for its potent antioxidative properties and therapeutic potential. This bioactive xanthone compound plays a crucial role in mitigating oxidative stress, which is a key factor in the pathogenesis of various diseases, including liver diseases. As a powerful natural antioxidant, MF exhibits a wide range of hepatoprotective effects, making it a promising candidate for liver disease therapy. In this review, we systematically examine the source and chemical properties, synthetic pathways, pharmacokinetic characteristics, and bioavailability enhancement strategies of MF. Furthermore, we explore its mechanisms of action in treating liver diseases, with a focus on its antioxidative properties and their role in modulating liver disease progression. Given the growing burden of…
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Taxonomy
TopicsMangiferin and Mango Extracts · Natural Compound Pharmacology Studies · Biochemical Acid Research Studies