# Unlocking Mangiferin: A Therapeutic Candidate Revolutionizing Liver Disease Therapy

## TL;DR

Mangiferin, a natural antioxidant found in fruits and herbs, shows promise as a new therapy for liver diseases due to its ability to reduce oxidative stress.

## Contribution

This review systematically explores mangiferin's properties, synthesis, bioavailability, and mechanisms in liver disease treatment.

## Key findings

- Mangiferin exhibits potent antioxidative effects crucial for liver disease mitigation.
- The compound shows hepatoprotective properties and potential for clinical application.
- Strategies to enhance mangiferin's bioavailability are discussed for improved therapeutic outcomes.

## Abstract

Mangiferin (MF), a natural component widely found in fruits, vegetables, and herbs, has garnered increasing attention for its potent antioxidative properties and therapeutic potential. This bioactive xanthone compound plays a crucial role in mitigating oxidative stress, which is a key factor in the pathogenesis of various diseases, including liver diseases. As a powerful natural antioxidant, MF exhibits a wide range of hepatoprotective effects, making it a promising candidate for liver disease therapy. In this review, we systematically examine the source and chemical properties, synthetic pathways, pharmacokinetic characteristics, and bioavailability enhancement strategies of MF. Furthermore, we explore its mechanisms of action in treating liver diseases, with a focus on its antioxidative properties and their role in modulating liver disease progression. Given the growing burden of liver disease and the limitations of current therapies, this review aims to promote the clinical application of MF as a therapeutic candidate, paving the way for innovative therapeutic strategies for liver diseases.