Case Report: successful treatment of severe bronchiectasis by inhalation of mesenchymal stem cell-derived exosomes

TL;DR

This case report shows that inhaling exosomes from stem cells may help treat severe bronchiectasis, improving breathing and quality of life.

Contribution

The study presents the first case of bronchiectasis treated with inhaled mesenchymal stem cell-derived exosomes.

Findings

Inhalation of MSCs-exosomes reversed hypoxemia in a bronchiectasis patient.

The treatment showed potential to improve clinical outcomes and quality of life.

This approach may reduce mortality in severe bronchiectasis cases.

Abstract

Bronchiectasis is a chronic respiratory disorder characterized by irreversible airway dilation and recurrent infections, remains a therapeutic challenge. MSCs-exosomes based treatment is a potential treatment for respiratory disease; however, data regarding the efficacy of this novel therapy are currently lacking. We present a case of bronchiectasis treated with inhaled exosomes derived from human umbilical cord mesenchymal stem cells. As demonstrated in this patient, MSCs-exosomes inhalation may provide comprehensive benefits including reversal of hypoxemia, which could potentially result in enhancement of clinical outcomes and quality of life, and reduction in mortality.

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