# Case Report: successful treatment of severe bronchiectasis by inhalation of mesenchymal stem cell-derived exosomes

## TL;DR

This case report shows that inhaling exosomes from stem cells may help treat severe bronchiectasis, improving breathing and quality of life.

## Contribution

The study presents the first case of bronchiectasis treated with inhaled mesenchymal stem cell-derived exosomes.

## Key findings

- Inhalation of MSCs-exosomes reversed hypoxemia in a bronchiectasis patient.
- The treatment showed potential to improve clinical outcomes and quality of life.
- This approach may reduce mortality in severe bronchiectasis cases.

## Abstract

Bronchiectasis is a chronic respiratory disorder characterized by irreversible airway dilation and recurrent infections, remains a therapeutic challenge. MSCs-exosomes based treatment is a potential treatment for respiratory disease; however, data regarding the efficacy of this novel therapy are currently lacking. We present a case of bronchiectasis treated with inhaled exosomes derived from human umbilical cord mesenchymal stem cells. As demonstrated in this patient, MSCs-exosomes inhalation may provide comprehensive benefits including reversal of hypoxemia, which could potentially result in enhancement of clinical outcomes and quality of life, and reduction in mortality.